Annual Report 2012 | Forschungszentrum Jülich Where Caffeine Takes Effect 23 October 2012 | Die Welt and other newspapers publish articles on findings by Jülich researchers who demonstrated that the stimulating effect of coffee unfolds primarily in areas of the cerebrum that are responsible for complex cognitive association and evaluation processes. The reports focus on the fact that caffeine acts in those regions of the brain that are affected by Alzheimer’s disease. Keynote Lecture 12 November 2012 | At Jülich’s end-of-year ceremony, 300 guests from politics, science, and industry listen to Prof. Thomas Lippert’s keynote lecture at the Rhineland Regional Museum in Bonn. He discusses how high-performance computing has changed science and what new findings are made possible by supercomputers. Computer simulations can build bridges between theory and practice in fields such as climate research, energy research, and brain research, and have become indispensable. Collapse under Thermal Pressure Calculated 12 November 2012 | Capsules with a diameter of a few micro- or even nanometres are being discussed as possible vehicles for transporting drugs to specific organs. According to computer simulations described by scientists from Jülich and Harvard in the journal PNAS, heat-related molecular movements adversely affect the stability of such capsules, which is why they collapse more easily under pressure than previously predicted. Molecular Spirals 24 October 2012 | Thread-like molecules, such as DNA, form spirals when they flow through microscopically small channels. Jülich scientists provide explanations for the forces that bring about this deformation in the journal Physical Review Letters. Understanding the flow behaviour of such molecules is important for the development of medical test disks that can be used to cheaply examine tiny amounts of blood. 13